Single-photon emission computed tomography (SPECT) is a nuclear medicine tomographic imaging technique using gamma rays.

The technique requires delivery of a gamma-emitting radiopharmaceutical into the patient, normally through injection into the bloodstream. The pharmacokinetic of the radiopharmaceutical in an organ allows studying the biology or the functionality of the considered organ. The pharmacokinetic is obtained by image quantification of the administered radiopharmaceutical. The perfusion and the functionality of the liver are evaluated trough the administration of respectively 99mTc-MAA and 99mTc-BRIDA.

SPECT imaging is performed by using a gamma camera to acquire multiple 2-D mages (also called projections), from multiple angles. Software is then used to apply a tomographic reconstruction algorithm to the multiple projections, yielding a 3-D data set. Tomographic reconstruction algorithm requires parameter definition and tandardization to allow reproducible quantification.

The aim of the master thesis is to define optimized SPECT reconstruction for liver functionality quantification with MIM Software after 99mTc-MAA or 99mTc-BRIDA administration.

Contacts:

Olivier Debeir odebeir@ulb.ac.be,

Nicolas Pauly Nicolas.Pauly@ulb.ac.be,

Vanderlinden Bruno bruno.vanderlinden@bordet.be,

Reynaert Nick Nick.Reynaert@bordet.be,

Marin Gwennaelle gwennaelle.marin@bordet.be