Extraction of robust morphological feature from medical images (CT-scan) of the aorta in the context of the Marfan syndrome.

  • Swimlane: Current
  • Column: Published
  • Position: 3
  • Assignee: Olivier Debeir
  • Creator: Olivier Debeir
  • Started:
  • Created: 21/04/2021 09:36
  • Modified: 09/10/2021 09:01
  • Moved: 09/10/2021 09:01
Description

Heritable Thoracic Aortic Diseases (HTAD) are genetic vascular diseases presenting thoracic aortic dilation, aneurysms or dissections on one or more aortic segments. Mortality of people with HTAD is mostly determined by aortic root aneurysm dissection and rupture.
Aortic dilation is generally not detected at an early stage.

Existing aorta measurement techniques are limited, and can deviate up to 10% depending on the examiner. This has implications for early diagnosis and for an optimal timing of preventive surgery.

Measurement inconsistency hampers the re-use of data and building large consistent datasets.

The project aims to help in extracting robust morphological feature from medical images (CT-scan) of the aorta.

The project will be done in collaboration with Fondation 101 Génomes.

Collaborations:

Assistance Publique des Hôpitaux de Paris (APHP), ETRO-VUB Department of Electronics and Informatics and FARI – AI for the Common Good Institute

Contact:

Christine Decaestecker cdecaes@ulb.ac.be, odebeir@ulb.ac.be

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Comments
Olivier Debeir
Olivier Debeir Created at: 01/07/2021 10:26 Updated at: 01/07/2021 10:26

contact Teams ce jour:

  • confirme son intérêt
  • OD va contacter Carl pour s'assurer des données
  • Cécile sera en mission enn RDC jusqu'en août et reprendra contact ensuite
  • il a été convenu qu'elle cheerche des db sur Kaggle / grand challenge pour se faire la main
Olivier Debeir
Olivier Debeir Created at: 17/07/2021 09:58 Updated at: 17/07/2021 09:58

HAMON Phrasie Phrasie.Hamon@ulb.be a aussi marqué son intérêt

Olivier Debeir
Olivier Debeir Created at: 17/08/2021 14:27 Updated at: 17/08/2021 14:27

https://jficv.com/usrfile/Presentation/2019/S18-P02.pdf

Olivier Debeir
Olivier Debeir Created at: 25/08/2021 08:22 Updated at: 25/08/2021 08:22

Jef Vandemeulebroucke

Tue, Aug 24, 8:28 AM (23 hours ago)

to DEBEIR, DECAESTECKER, MORCH
Dear Olivier, Christine,

A short update from Materialise.

As Carl has forwarded (28/06), materialise would be willing to support the project. The main ideas that we discussed were:

  • Using mimics to generate ground truth segmentations
  • Potentially part of the process could be further automated using the mimics python interface. Writing such a script could form part the thesis if deemed relevant
  • Materialise does not expect any access to data.
  • They did express an interest in showcasing any successful result (e.g. at events or on their website) using the scripting interface (without claiming any of the IP)
  • In case the work on generating ground truths (with or without scripting interface) is successful, they would appreciate an acknowledgement in publications or presentations

For access to the mimics software:

  • Materialise would prefer to host the student for a period and provide support in performing the work (Leuven)
  • In case this would be complicated for the student, we can still try to obtain a license for a short duration. In case you have an installation somewhere, this installation could be extended with the required toolboxes (CT Heart Tool and scripting interface) and they may be more cooperative (we had one at UZ Brussel, I can check whether it is still possible)

The person to contact would be Patricia.Lopes@materialise.be

  • She collaborated with us before and is very skilled in heart segmentation

I have proposed the topic at VUB. No response sofar. In case use of Mimics seems relevant for the ULB student, I could facilitate the contact with Materialise.

I will be off from 27/08 onwards. I can be contacted on my cell in case of urgent matters.

Regards,
jef

Olivier Debeir
Olivier Debeir Created at: 02/09/2021 13:25 Updated at: 02/09/2021 13:25

https://eds.aphp.fr/demande-acces-donnees

Olivier Debeir
Olivier Debeir Created at: 02/09/2021 16:50 Updated at: 02/09/2021 16:50

romain.alderweireldt@f101g.org

1:53 PM (2 hours ago)

to MORCH, DEBEIR, JONDEAU

Comme discuté, pourrions-nous imaginer contacter l’équipe ‘Pears’ Treasure/Pepper/Rega/Golworthy ( https://exstent.com/news/) pour accéder à un premier set de données ?

Il est question dans cette publication récente d’au moins 200 patients : https://heart.bmj.com/content/early/2021/07/29/heartjnl-2021-319300.

Professeur Jondeau avez-vous un contact avec les Professeurs Treasure et Pepper à recommander avec Carl?

Voici déjà les coordonnées du Prof Rega : filip.rega@med.kuleuven.be

Bien à vous,

Romain