The role of SPECT/CT images for bone marrow dosimetry during neuroendocrine tumor therapy with 177Lu-DOTATATE

  • Category: BORDET
  • Swimlane: 2020-2021
  • Column: Done
  • Position: 3
  • Assignee: Olivier Debeir
  • Creator: Olivier Debeir
  • Started:
  • Created: 18/05/2020 10:33
  • Modified: 01/09/2021 06:46
  • Moved: 01/09/2021 06:46
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  • annulé
Description

Background:

Neuroendocrine tumors (NETs) are abnormal cell growths that begin in the neuroendocrine (hormone-producing) cells which are distributed widely throughout the body. Most NETs over-express somatostatin receptors. For this reason, peptide receptor radionuclide therapy with 177Lutetium-DOTA-Tyr³-octreotate (177Lu-DOTATATE) is an effective therapeutic option for NETs. Octreotate is a synthetic analog of somatostatin and will thus attaches to the NETs somatostatin receptors. 177Lu will deliver a high dose to the tumor through electron emissions. 177Lu also emits γ photons which allow for repeated SPECT/CT acquisitions after the administration of 177Lu-DOTATATE. As the bone marrow is an important organ-at-risk for this therapy, we want to investigate to which extend the SPECT/CT images can be used to measure the dose delivered to the bone marrow.

Goal:

The goal of this Master thesis is to investigate to which extend the SPECT/CT images can be used for bone marrow dosimetry in 177Lu-DOTATATE therapy. First the Master student will study the available literature on the subject. Secondly the student will implement a tool for automated bone marrow segmentation on SPECT/CT images. Thirdly he/she will perform the dosimetry of the bone marrow based on the activity measured on SPECT images. Finally, the dosimetry results obtained with SPECT/CT images will be compared to those obtained with blood sample measurements (current gold standard for bone marrow dosimetry).

Promoters:

gwennaelle.marin@bordet.be

bruno.vanderlinden@bordet.be

Olivier Debeir odebeir@ulb.ac.be

Nicolas Pauly Nicolas.Pauly@ulb.be

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